Fibrillatory activity type rotor in cardiac tissue: study on in silicone and in vitro models

Project Details

Description

Atrial fibrillation (af) is the most common tachycardia in clinical practice. although there have been advances in the treatment of af, the results are still sub-optimal. this is mainly due to the lack of knowledge that still exists about the physiopathological mechanisms that cause its initiation and maintenance. the most recently proposed mechanism to explain af is the rotor hypothesis. studies aimed at clarifying the physiopathological mechanisms by which the rotors maintain and perpetuate af, would allow to improve the tools for its detection and thus improve the treatments of said pathology. it is proposed to carry out a study of the electrophysiological activity in cardiac tissue, using in silico and in vitro models. on the one hand, by computer simulation,implementing two-dimensional models of atrial cardiac tissue, and simultaneously, in cardiomyocyte cultures in vitro, by means of optical mapping techniques.

Objective

To analyze the rotor-like fibrillatory activity in cardiac tissue, using in silico and in vitro models.

Expected results

Article isi wos or scopus accepted, master's student link, undergraduate student's link and lecture in international scientific event, with publication in memoirs
StatusFinished
Effective start/end date1/08/1730/07/18

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