Effect of air pollutants in the aburra valley on cardiac electrical activity: study in in silico and in vitro models

Project Details

Description

Air pollution increases the risk of cardiovascular disease mortality. cardiac arrhythmias are the first cause of morbidity and mortality, and one of the pathologies that
more expense generated in health systems. the metropolitan area of ??the aburrá valley is experiencing an epidemic of mortality due to diseases associated with environmental pollution. several studies have reported harmful effects on the cardiac system; however, the underlying mechanisms have not been well established. this work aims to study the effects of atmospheric pollutants in the aburrá valley metropolitan area on cardiac electrical activity, using in silico and in vitro models. for which, particulate material (pm of its
acronym in english) in different environmental monitoring stations of the metropolitan area of ??the aburrá valley, which will be characterized physically and chemically, on the other hand, information will be collected
of the concentration of pollutants such as co, nox and so2. a lichen exposure chamber (pollution bioindicators will be developed
atmospheric) and in vitro cultures of cardiomyocytes to the atmospheric pollutants of the aburrá valley metropolitan area, in order to assess physiological effects. further,
a study of the cytotoxic and genotoxic effect on cardiomyocytes will be performed. based on the information collected, and through the development of multi-scale models of the
cardiac electrical functioning and mathematical models of the effect of atmospheric pollutants, simulation studies will be carried out to evaluate the effect that atmospheric pollutants, at the concentrations observed in the aburrá valley metropolitan area, cause on the electrophysiological characteristics, dynamics electrical, the generation of pro-arrhythmic conditions and pathological events. finally, by implementing an optical mapping device, the effect of atmospheric pollutants on the electrical activity of in vitro models of cardiomyocytes will be evaluated. using in silico and in vitro tools, progress will be made in the knowledge of the effects that air pollution in the metropolitan area of ??the aburrá valley has on cardiac tissue and the appearance of arrhythmias, giving greater clarity on the mechanisms that these pollutants present about the risk of heart disease; allowing the
improvement of the prevention methods of these pathologies.

Objective

To study the effects of the atmospheric pollutants of the metropolitan area of ??the aburrá valley on the cardiac electrical activity, using in silico and in vitro models. it is specific to characterize the particulate material physically and chemically and determine the concentrations of the other atmospheric pollutants obtained in different points of the metropolitan area of ??the aburrá valley.
to assess the physiological effect on bioindicating lichens of air quality and cytotoxic and genotoxic behavior in cardiomyocytes, indicated by exposure to air pollutants from the metropolitan area of ??the aburrá valley. evaluate in silico models the effect of atmospheric pollutants, at the concentrations observed in the metropolitan area of ??the aburrá valley, on the cardiac electrical activity and arrhythmic episodes. evaluate by means of optical mapping techniques, the effect of atmospheric pollutants from the metropolitan area of ??the aburrá valley, on the electrical activity of cardiomyocytes in in vitro models and compare this behavior with the results of in silico model

Expected results

Articles category 4. presentations 3. training of undergraduate students. training of masters students. linking phd students
StatusActive
Effective start/end date28/11/1828/11/21

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