Effect of atmospheric pollutants on atrial electrical activity. study in silico

Project Details

Description

Cardiac arrhythmias are the leading cause of morbidity and mortality, and one of the pathologies that generates the most expense in healthcare systems, with atrial fibrillation being the most common type of sustained cardiac arrhythmia. air pollution increases the risk of mortality from cardiovascular disease. medellín and the metropolitan area of ??the aburra valley live today an epidemic of mortality due to diseases associated with environmental pollution. several studies have reported harmful effects on the cardiac system, however, the underlying mechanisms have not been well established. the objective of this work is the in silico study of the effects of atmospheric pollutants on cardiac electrical activity, specifically in the atria. for which, simulation studies will be carried out,through the development and implementation of unicellular and two-dimensional virtual models of atrial tissue (2d), that simulate atrial electrical functioning at the cellular and tissue levels. the effect of the main atmospheric pollutants at different concentrations on cellular electrophysiological characteristics, on electrical dynamics, the generation of pro-arrhythmic conditions and pathological events such as rotors and reentries will be studied. for the efficient resolution of the equations and the visualization of propagation patterns in multi-scale structures, advanced scientific computing techniques will be used.the effect of the main atmospheric pollutants at different concentrations on cellular electrophysiological characteristics, on electrical dynamics, the generation of pro-arrhythmic conditions and pathological events such as rotors and reentries will be studied. for the efficient resolution of the equations and the visualization of propagation patterns in multi-scale structures, advanced scientific computing techniques will be used.the effect of the main atmospheric pollutants at different concentrations on cellular electrophysiological characteristics, on electrical dynamics, the generation of pro-arrhythmic conditions and pathological events such as rotors and reentries will be studied. for the efficient resolution of the equations and the visualization of propagation patterns in multi-scale structures, advanced scientific computing techniques will be used.for the efficient resolution of the equations and the visualization of propagation patterns in multi-scale structures, advanced scientific computing techniques will be used.for the efficient resolution of the equations and the visualization of propagation patterns in multi-scale structures, advanced scientific computing techniques will be used.

Objective

To study the effects of atmospheric pollutants on atrial electrical activity and arrhythmic episodes, using in silico models.

Expected results

Article isi wos or scopus, submitted. linking a master's student. publication in memories of scientific event
StatusFinished
Effective start/end date16/01/1731/01/18

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