Study of the pupillary light reflex in children with attention deficit hyperactivity disorder and its comorbidity with circadian rhythm sleep disorders

Project Details


Several studies have shown that intrinsically photosensitive or melanopsin-expressing ganglion cells “iprgcs” contribute to both the pupillary light reflex (rpl) and the circadian rhythm. Currently, the application of pupillometry has gained strength in the study of various diseases, it has been used as a tool in the evaluation and non-invasive study of retinal function, of the autonomic nervous system (ANS) and the relationship with chronobiology and sleep disorders, through the characterization and isolation of the contributions of cones, rods, and iprgc to the rpl. Problems in the regulation of the sna have been described in several studies on neurodevelopmental disorders (odd) such as attention deficit hyperactivity disorder (adhd). On the other hand, sleep disturbances have been reported in more than 80% of children with ODD.


To evaluate the functions of the autonomic nervous system and circadian rhythmicity in a group of patients with ADHD and compare them to healthy individuals.

Expected results

Isi wos or scopus article, accepted. No study to date has used a protocol for evaluating the contributions of iprgcs to rpl in both disorders, also linked to the use of actimetry, in order to clarify whether there is a relationship between the integrity of iprgcs and symptomatology described. in addition to being able to identify possible biomarkers for diagnosis. The generation of new knowledge is expected to contribute to the diagnosis, treatment and understanding of the physiological and cognitive processes that underlie ODDs such as ADHD and AS.
Short titleReflejo Pupilar
AcronymReflejo Pupilar
Effective start/end date28/09/2130/03/23


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