Atrial Rotor Modulation by Localized Dofetilide Application: An in Silico Study

Sandra Perez-Buitrago, Juan P. Ugarte, Catalina Tobon

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations


The rotor ablation has gained favor in recent years to treat chronic atrial fibrillation (CAF). However, it may cause complications in patients and the results remain suboptimal. Besides, antiarrhythmic drugs for the management of AF are not sufficiently effective and can cause significant cardiac and extracardiac side effects. To reduce the risk and increase the effectiveness, a rotor modulation via the localized release of dofetilide is proposed through an in silico study. A computational model of two-dimensional atrial tissue was implemented using human cell model under CAF conditions. Dofetilide was modeled blocking the ionic currents IKr and IKACH using Hill's equation. A CAF episode, sustained by a rotor, was simulated. Different concentrations of dofetilide were applied in specific distributions based on the rotor tip location, detected by phase map analysis. Non-localized application of dofetilide resulted in the benefit of CAF progression. In contrast, localized dofetilide liberation terminated the CAF episode. These results could have therapeutic implications in novel treatments of CAF.

Original languageEnglish
Title of host publicationComputing in Cardiology Conference, CinC 2018
PublisherIEEE Computer Society
ISBN (Electronic)9781728109589
StatePublished - 1 Sep 2018
Event45th Computing in Cardiology Conference, CinC 2018 - Maastricht, Netherlands
Duration: 23 Sep 201826 Sep 2018

Publication series

NameComputing in Cardiology
ISSN (Print)2325-8861
ISSN (Electronic)2325-887X


Conference45th Computing in Cardiology Conference, CinC 2018


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