Sulfur Dioxide Effects on Human Atrial Action Potential: In Silico Study

Laura C. Palacio, Geraldine Durango, Juan P. Ugarte, Javier Saiz, Catalina Tobon

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations


Exposure to air pollutants agents, like sulfur dioxide (SO2), has significant effects on the cardiovascular system. Studies have shown that SO2 blocks ICaL and increases the INa, IK1 and Ito currents, which implies action potential duration (APD) decrease, favoring the initiation of atrial arrhythmias. This study aims to assess the effects of the SO2 at different concentrations on human atrial action potential, using computational simulation. For this, based on experimental data, we developed concentration-dependent equations to simulate the SO2 effects on the currents. They were incorporated in the Courtemanche model of human atrial cell and in a 2D model of atrial tissue. S1-S2 cross-field protocol was applied to initiate a rotor. SO2 concentrations from 0 to 100 μ M were implemented. Our results are in agreement with results from non-human in vitro and in vivo studies. The SO2 causes APD shortening and loss of plateau phase in a fraction that increases as the concentration increases. In the 2D model, a rotor can be generated from 50 μ M of SO2 concentration, showing a pro-arrhythmic effect.

Original languageEnglish
Title of host publicationComputing in Cardiology Conference, CinC 2018
PublisherIEEE Computer Society
ISBN (Electronic)9781728109589
StatePublished - 1 Sep 2018
Event45th Computing in Cardiology Conference, CinC 2018 - Maastricht, Netherlands
Duration: 23 Sep 201826 Sep 2018

Publication series

NameComputing in Cardiology
ISSN (Print)2325-8861
ISSN (Electronic)2325-887X


Conference45th Computing in Cardiology Conference, CinC 2018


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