Atrial Rotor Modulation by Localized Dofetilide Application: An in Silico Study

Sandra Perez-Buitrago, Juan P. Ugarte, Catalina Tobon

Resultado de la investigación: Capítulo del libro/informe/acta de congresoContribución a la conferencia

Resumen

The rotor ablation has gained favor in recent years to treat chronic atrial fibrillation (CAF). However, it may cause complications in patients and the results remain suboptimal. Besides, antiarrhythmic drugs for the management of AF are not sufficiently effective and can cause significant cardiac and extracardiac side effects. To reduce the risk and increase the effectiveness, a rotor modulation via the localized release of dofetilide is proposed through an in silico study. A computational model of two-dimensional atrial tissue was implemented using human cell model under CAF conditions. Dofetilide was modeled blocking the ionic currents IKr and IKACH using Hill's equation. A CAF episode, sustained by a rotor, was simulated. Different concentrations of dofetilide were applied in specific distributions based on the rotor tip location, detected by phase map analysis. Non-localized application of dofetilide resulted in the benefit of CAF progression. In contrast, localized dofetilide liberation terminated the CAF episode. These results could have therapeutic implications in novel treatments of CAF.

Idioma originalInglés
Título de la publicación alojadaComputing in Cardiology Conference, CinC 2018
EditorialIEEE Computer Society
ISBN (versión digital)9781728109589
DOI
EstadoPublicada - 1 sep 2018
Evento45th Computing in Cardiology Conference, CinC 2018 - Maastricht, Países Bajos
Duración: 23 sep 201826 sep 2018

Serie de la publicación

NombreComputing in Cardiology
Volumen2018-September
ISSN (versión impresa)2325-8861
ISSN (versión digital)2325-887X

Conferencia

Conferencia45th Computing in Cardiology Conference, CinC 2018
PaísPaíses Bajos
CiudadMaastricht
Período23/09/1826/09/18

Huella Profundice en los temas de investigación de 'Atrial Rotor Modulation by Localized Dofetilide Application: An in Silico Study'. En conjunto forman una huella única.

  • Citar esto

    Perez-Buitrago, S., Ugarte, J. P., & Tobon, C. (2018). Atrial Rotor Modulation by Localized Dofetilide Application: An in Silico Study. En Computing in Cardiology Conference, CinC 2018 [8744008] (Computing in Cardiology; Vol. 2018-September). IEEE Computer Society. https://doi.org/10.22489/CinC.2018.359