Carbon Monoxide Effect on Human Cardiac Tissue. In Silico Study

Catalina Tobón, Geraldine Durango-Giraldo, Juan Pablo Ugarte

Resultado de la investigación: Capítulo del libro/informe/acta de congresoContribución a la conferenciarevisión exhaustiva

Resumen

The Exposure to atmospheric pollutants, such as carbon monoxide (CO), promotes the appearance of cardiovascular diseases. Studies have shown that CO blocks calcium channels, leading to a decrease of the ICaL current and to a shortening of the action potential duration (APD); favoring the generation of cardiac arrhythmias. The aim of this work is to study the CO effects, at different concentrations, on the atrial and ventricular tissues using computational simulations. An equation of the CO effect on ICaL was developed. It was included in two mathematical models of human atrial and ventricular cells, under normal physiological conditions. Atrial and ventricular 2D models were developed to evaluate the CO effect on the generation of reentries as an arrhythmogenic mechanism. The results show that CO blocks the ICaL current in a greater fraction as its concentration increases, causing APD shortening. Such effect is larger in atrial cardiomycytes. Arrhythmic events (rotors) were generated at the high CO concentration in atrial tissue. In ventricular tissue it was not possible to generate rotors. This study provides a first step in investigating the proarrhythmic effects of CO in healthy people.

Idioma originalInglés
Título de la publicación alojadaApplied Computer Sciences in Engineering - 8th Workshop on Engineering Applications, WEA 2021, Proceedings
EditoresJuan Carlos Figueroa-García, Yesid Díaz-Gutierrez, Elvis Eduardo Gaona-García, Alvaro David Orjuela-Cañón
EditorialSpringer Science and Business Media Deutschland GmbH
Páginas160-170
Número de páginas11
ISBN (versión impresa)9783030867010
DOI
EstadoPublicada - 2021
Evento8th Workshop on Engineering Applications, WEA 2021 - Virtual, Online
Duración: 6 oct 20218 oct 2021

Serie de la publicación

NombreCommunications in Computer and Information Science
Volumen1431 CCIS
ISSN (versión impresa)1865-0929
ISSN (versión digital)1865-0937

Conferencia

Conferencia8th Workshop on Engineering Applications, WEA 2021
CiudadVirtual, Online
Período6/10/218/10/21

Tipos de productos de Colciencias

  • Artículo C - Q4

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