Entropy mapping approach for functional reentry detection in atrial fibrillation: An in-silico study

Juan P. Ugarte, Catalina Tobón, Andrés Orozco-Duque

Resultado de la investigación: Contribución a una revistaArtículoInvestigaciónrevisión exhaustiva

Resumen

Catheter ablation of critical electrical propagation sites is a promising tool for reducing the recurrence of atrial fibrillation (AF). The spatial identification of the arrhythmogenic mechanisms sustaining AF requires the evaluation of electrograms (EGMs) recorded over the atrial surface. This work aims to characterize functional reentries using measures of entropy to track and detect a reentry core. To this end, different AF episodes are simulated using a 2D model of atrial tissue. Modified Courtemanche human action potential and Fenton-Karma models are implemented. Action potential propagation is modeled by a fractional diffusion equation, and virtual unipolar EGM are calculated. Episodes with stable and meandering rotors, figure-of-eight reentry, and disorganized propagation with multiple reentries are generated. Shannon entropy (ShEn), approximate entropy (ApEn), and sample entropy (SampEn) are computed from the virtual EGM, and entropy maps are built. Phase singularity maps are implemented as references. The results show that ApEn and SampEn maps are able to detect and track the reentry core of rotors and figure-of-eight reentry, while the ShEn results are not satisfactory. Moreover, ApEn and SampEn consistently highlight a reentry core by high entropy values for all of the studied cases, while the ability of ShEn to characterize the reentry core depends on the propagation dynamics. Such features make the ApEn and SampEn maps attractive tools for the study of AF reentries that persist for a period of time that is similar to the length of the observation window, and reentries could be interpreted as AF-sustaining mechanisms. Further research is needed to determine and fully understand the relation of these entropy measures with fibrillation mechanisms other than reentries.

Idioma originalInglés
Número de artículo194
PublicaciónEntropy
Volumen21
N.º2
DOI
EstadoPublicada - 1 feb 2019

Huella dactilar

fibrillation
reentry
entropy
propagation
sustaining
rotors

Palabras clave

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    title = "Entropy mapping approach for functional reentry detection in atrial fibrillation: An in-silico study",
    abstract = "Catheter ablation of critical electrical propagation sites is a promising tool for reducing the recurrence of atrial fibrillation (AF). The spatial identification of the arrhythmogenic mechanisms sustaining AF requires the evaluation of electrograms (EGMs) recorded over the atrial surface. This work aims to characterize functional reentries using measures of entropy to track and detect a reentry core. To this end, different AF episodes are simulated using a 2D model of atrial tissue. Modified Courtemanche human action potential and Fenton-Karma models are implemented. Action potential propagation is modeled by a fractional diffusion equation, and virtual unipolar EGM are calculated. Episodes with stable and meandering rotors, figure-of-eight reentry, and disorganized propagation with multiple reentries are generated. Shannon entropy (ShEn), approximate entropy (ApEn), and sample entropy (SampEn) are computed from the virtual EGM, and entropy maps are built. Phase singularity maps are implemented as references. The results show that ApEn and SampEn maps are able to detect and track the reentry core of rotors and figure-of-eight reentry, while the ShEn results are not satisfactory. Moreover, ApEn and SampEn consistently highlight a reentry core by high entropy values for all of the studied cases, while the ability of ShEn to characterize the reentry core depends on the propagation dynamics. Such features make the ApEn and SampEn maps attractive tools for the study of AF reentries that persist for a period of time that is similar to the length of the observation window, and reentries could be interpreted as AF-sustaining mechanisms. Further research is needed to determine and fully understand the relation of these entropy measures with fibrillation mechanisms other than reentries.",
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    author = "Ugarte, {Juan P.} and Catalina Tob{\'o}n and Andr{\'e}s Orozco-Duque",
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    language = "Ingl{\'e}s",
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    journal = "Entropy",
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    Entropy mapping approach for functional reentry detection in atrial fibrillation : An in-silico study. / Ugarte, Juan P.; Tobón, Catalina; Orozco-Duque, Andrés.

    En: Entropy, Vol. 21, N.º 2, 194, 01.02.2019.

    Resultado de la investigación: Contribución a una revistaArtículoInvestigaciónrevisión exhaustiva

    TY - JOUR

    T1 - Entropy mapping approach for functional reentry detection in atrial fibrillation

    T2 - An in-silico study

    AU - Ugarte, Juan P.

    AU - Tobón, Catalina

    AU - Orozco-Duque, Andrés

    PY - 2019/2/1

    Y1 - 2019/2/1

    N2 - Catheter ablation of critical electrical propagation sites is a promising tool for reducing the recurrence of atrial fibrillation (AF). The spatial identification of the arrhythmogenic mechanisms sustaining AF requires the evaluation of electrograms (EGMs) recorded over the atrial surface. This work aims to characterize functional reentries using measures of entropy to track and detect a reentry core. To this end, different AF episodes are simulated using a 2D model of atrial tissue. Modified Courtemanche human action potential and Fenton-Karma models are implemented. Action potential propagation is modeled by a fractional diffusion equation, and virtual unipolar EGM are calculated. Episodes with stable and meandering rotors, figure-of-eight reentry, and disorganized propagation with multiple reentries are generated. Shannon entropy (ShEn), approximate entropy (ApEn), and sample entropy (SampEn) are computed from the virtual EGM, and entropy maps are built. Phase singularity maps are implemented as references. The results show that ApEn and SampEn maps are able to detect and track the reentry core of rotors and figure-of-eight reentry, while the ShEn results are not satisfactory. Moreover, ApEn and SampEn consistently highlight a reentry core by high entropy values for all of the studied cases, while the ability of ShEn to characterize the reentry core depends on the propagation dynamics. Such features make the ApEn and SampEn maps attractive tools for the study of AF reentries that persist for a period of time that is similar to the length of the observation window, and reentries could be interpreted as AF-sustaining mechanisms. Further research is needed to determine and fully understand the relation of these entropy measures with fibrillation mechanisms other than reentries.

    AB - Catheter ablation of critical electrical propagation sites is a promising tool for reducing the recurrence of atrial fibrillation (AF). The spatial identification of the arrhythmogenic mechanisms sustaining AF requires the evaluation of electrograms (EGMs) recorded over the atrial surface. This work aims to characterize functional reentries using measures of entropy to track and detect a reentry core. To this end, different AF episodes are simulated using a 2D model of atrial tissue. Modified Courtemanche human action potential and Fenton-Karma models are implemented. Action potential propagation is modeled by a fractional diffusion equation, and virtual unipolar EGM are calculated. Episodes with stable and meandering rotors, figure-of-eight reentry, and disorganized propagation with multiple reentries are generated. Shannon entropy (ShEn), approximate entropy (ApEn), and sample entropy (SampEn) are computed from the virtual EGM, and entropy maps are built. Phase singularity maps are implemented as references. The results show that ApEn and SampEn maps are able to detect and track the reentry core of rotors and figure-of-eight reentry, while the ShEn results are not satisfactory. Moreover, ApEn and SampEn consistently highlight a reentry core by high entropy values for all of the studied cases, while the ability of ShEn to characterize the reentry core depends on the propagation dynamics. Such features make the ApEn and SampEn maps attractive tools for the study of AF reentries that persist for a period of time that is similar to the length of the observation window, and reentries could be interpreted as AF-sustaining mechanisms. Further research is needed to determine and fully understand the relation of these entropy measures with fibrillation mechanisms other than reentries.

    KW - Approximate entropy

    KW - Atrial fibrillation

    KW - Entropy maps

    KW - Fractionated electrograms

    KW - Functional reentry

    KW - Sample entropy

    KW - Shannon entropy

    UR - http://www.scopus.com/inward/record.url?scp=85061976167&partnerID=8YFLogxK

    U2 - 10.3390/e21020194

    DO - 10.3390/e21020194

    M3 - Artículo

    VL - 21

    JO - Entropy

    JF - Entropy

    SN - 1099-4300

    IS - 2

    M1 - 194

    ER -