Fractional Diffusion Modulates Distribution of Action Potential Duration in Fibrotic Atrial Strands

Juan P. Ugarte, Catalina Tobon, Laura C. Palacio, Henry Andrade-Caicedo, Javier Saiz

Resultado de la investigación: Capítulo del libro/informe/acta de congresoContribución a la conferencia

Resumen

Background: Fibroblast proliferation, as a component of the fibrotic process, plays a role in structural remodeling, but also can alter the electrophysiology of the cardiomyocytes. Aim: To study the action potential duration dispersion (dAPD) in fibrotic atrial strands, where fibroblasts exerts both, structural and electrical influence on the propagation, using a fractional diffusion model. Methods: The Courtemanche model of human atrial cell is implemented under chronic atrial fibrillation (AF) remodeling conditions. The atrial strands are designed as 1D domains, having a fibrotic portion localized in the middle. Fibrosis is modeled taking into account an electrical component, implemented by coupling a number of fibroblasts to a single cardiomyocyte, and a structural component, implemented through a q-order fractional derivative. Results: The variations of q define two dAPD dispersion regimes. For q < 1.4, the fibrosis density and the number of fibroblast per cardiomyocyte do not alter the dAPD. For q ≥ 1.4, the dAPD depends on the fibrosis spatial characteristics. Conclusion: This study shows that the structural component of fibrosis, modeled using fractional diffusion, modulates the spatial dAPD in a domain including electrical coupling of cardiomyocytes and fibroblasts, under chronic AF conditions.

Idioma originalInglés
Título de la publicación alojadaComputing in Cardiology Conference, CinC 2018
EditorialIEEE Computer Society
ISBN (versión digital)9781728109589
DOI
EstadoPublicada - 1 sep 2018
Evento45th Computing in Cardiology Conference, CinC 2018 - Maastricht, Países Bajos
Duración: 23 sep 201826 sep 2018

Serie de la publicación

NombreComputing in Cardiology
Volumen2018-September
ISSN (versión impresa)2325-8861
ISSN (versión digital)2325-887X

Conferencia

Conferencia45th Computing in Cardiology Conference, CinC 2018
PaísPaíses Bajos
CiudadMaastricht
Período23/09/1826/09/18

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  • Citar esto

    Ugarte, J. P., Tobon, C., Palacio, L. C., Andrade-Caicedo, H., & Saiz, J. (2018). Fractional Diffusion Modulates Distribution of Action Potential Duration in Fibrotic Atrial Strands. En Computing in Cardiology Conference, CinC 2018 [8743753] (Computing in Cardiology; Vol. 2018-September). IEEE Computer Society. https://doi.org/10.22489/CinC.2018.228