Human Atrial Electrophysiological Models Under Fractional Derivative: Depolarization and Repolarization Dynamics During Normal and Fibrillation Conditions

Juan P. Ugarte, Catalina Tobón

Resultado de la investigación: Capítulo del libro/informe/acta de congresoContribución a la conferencia

Resumen

Atrial fibrillation (AF) is the most common arrhythmia within the clinical context. Advanced stages of the AF involve several difficulties in its management and treatment. This occurs mostly because the initiation and perpetuation mechanisms of the AF are still not fully understood. Cardiac scientific computation has become an important tool in researching the underlying mechanisms of the AF. In this work, an equation of action potential propagation that implements fractional order derivatives is used to model the atrial dynamics. The fractional derivative order represents the structural heterogeneities of the atrial myocardium. Using such mathematical operator, the Courtemanche and Maleckar human atrial electrophysiological models, during healthy and AF conditions, are assessed. The results indicate that, through the fractional order variations, there are electrophysiological properties whose behavior do not depend on the cellular model or physiological conditions. On the other hand, there are properties whose behavior under distinct values of the fractional order, are specific to the cellular model and to the physiological condition and they can be characterized quantitatively and qualitatively. Therefore, the fractional atrial propagation model can be a useful tool for modeling a wide range of electrophysiological scenarios in both healthy and AF conditions.

Idioma originalInglés
Título de la publicación alojadaApplied Computer Sciences in Engineering - 6th Workshop on Engineering Applications, WEA 2019, Proceedings
EditoresJuan Carlos Figueroa-García, Mario Duarte-González, Sebastián Jaramillo-Isaza, Alvaro David Orjuela-Cañon, Yesid Díaz-Gutierrez
EditorialSpringer Heidelberg
Páginas440-450
Número de páginas11
ISBN (versión impresa)9783030310189
DOI
EstadoPublicada - 1 ene 2019
Evento6th Workshop on Engineering Applications, WEA 2019 - Santa Marta, Colombia
Duración: 16 oct 201918 oct 2019

Serie de la publicación

NombreCommunications in Computer and Information Science
Volumen1052
ISSN (versión impresa)1865-0929
ISSN (versión digital)1865-0937

Conferencia

Conferencia6th Workshop on Engineering Applications, WEA 2019
PaísColombia
CiudadSanta Marta
Período16/10/1918/10/19

Huella Profundice en los temas de investigación de 'Human Atrial Electrophysiological Models Under Fractional Derivative: Depolarization and Repolarization Dynamics During Normal and Fibrillation Conditions'. En conjunto forman una huella única.

  • Citar esto

    Ugarte, J. P., & Tobón, C. (2019). Human Atrial Electrophysiological Models Under Fractional Derivative: Depolarization and Repolarization Dynamics During Normal and Fibrillation Conditions. En J. C. Figueroa-García, M. Duarte-González, S. Jaramillo-Isaza, A. D. Orjuela-Cañon, & Y. Díaz-Gutierrez (Eds.), Applied Computer Sciences in Engineering - 6th Workshop on Engineering Applications, WEA 2019, Proceedings (pp. 440-450). (Communications in Computer and Information Science; Vol. 1052). Springer Heidelberg. https://doi.org/10.1007/978-3-030-31019-6_38