Lead (Pb++) effect on human atrial action potential under normal and atrial fibrillation conditions. In silico study

Catalina Tobón, D. Pachajoa, J. P. Ugarte, J. Saiz

Resultado de la investigación: Contribución a una conferenciaPaper

Resumen

© Springer Nature Singapore Pte Ltd. 2017. Lead (Pb++) is a toxic agent that can exert adverse effects on the cardiac human health. Pb++blocks the Ltype Ca++channels. A decrease in L-type calcium current (ICaL) is an important mechanism favoring atrial fibrillation. It is important to study the electrophysiological Pb++effects on the atrial action potential in healthy people and those with AF. For this, we study the consequences of Pb++on action potential, under normal and atrial fibrillation condition using in silico models. Our results suggest that Pb++blocks ICaLcurrent in a fraction greater as the concentration increases, resulting in an action potential duration shortening, Pb++has a greater action potential duration effect on control conditions. To our knowledge, this is the first work that has developed mathematical models of Pb++effect on ICaLcurrent to study its effect on human atrial action potential.
Idioma originalInglés estadounidense
Páginas66-69
Número de páginas4
DOI
EstadoPublicada - 1 ene 2017
EventoIFMBE Proceedings -
Duración: 1 ene 2017 → …

Conferencia

ConferenciaIFMBE Proceedings
Período1/01/17 → …

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